Dr Charles N. Rotimi

Director, Center for Research on Genomics and Global Health (CRGGH)

Email: rotimic@hgm2010.org
Webpage link: crggh.nih.gov

Charles Rotimi, PhD, a genetic epidemiologist and a biochemist, is a senior investigator in the Inherited Disease Branch of the NHGRI intramural program. He is the Director of the Center for Research on Genomics and Global Health (CRGGH). The mission of this new trans-NIH center is to advance research into the role of culture, lifestyle, genetics and genomics in disease etiology and health disparities. Dr. Rotimi develops genetic epidemiology models and conducts population genetics research that explores the patterns and determinants of common complex diseases in human populations with particular emphasis on populations of the African Diaspora. As a senior investigator and director of the CRGGH, Dr. Rotimi leads a team of researchers across multiple disciplines (Medicine, genetics/genomics, epidemiology, statistics and informatics) to understand the complex interactions between inherited characteristics and environmental factors in disease susceptibility, variable drug response and health disparities. For example, his team conducted the first GWAS of an African American cohort that identified several genetic variants including PMS1, SLC24A4, YWHA7, IPO7, and CACANA1H underlying susceptibility to Hypertension and blood pressure control.  His lab also conducted the first and only genome-wide linkage study of Type 2 Diabetes in West Africans (the AADM Study). Dr. Rotimi’s lab continues to contribute to the global understanding of human genetic variation and its implication for differential disease distribution, variable drug response and human migration history. He is the current president of the African Society of Human Genetics (www.afshg.org).



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