Dr Ruan Yijun

Senior Group Leader
Assoc Director, Genomic Technologies

Email: ruanyj@hgm2010.org
Webpage link: http://www.gis.a-star.edu.sg/internet/site/investigators_user_id=19&f;=cv

My primary interest is to elucidate the structures and dynamics of all functional DNA elements in complex genomes through transcriptome characterizations and genome interrogation. To facilitate such understanding we have developed paired-end-ditag (PET) based high throughput and high precision DNA sequencing and mapping methodologies. We are applying these sequencing-based measurements to address complex biological questions such as how cancer cells progress and how stem cells maintain their unique properties. Another major interest of mine is to discover previously uncharacterized microbial genes and genomes that are relevant to human health. To this end, we have established a metagenome analysis capability that includes a filtration system for isolating uncultured microbes, shotgun and PET sequencing of metagenomes to uncover viral and bacterial genome sequences from a variety of environment settings and cavities of the human body.