Prof Emmanouil Dermitzakis

Department of Genetic Medicine and Development
University of Geneva Medical School


Emmanouil Dermitzakis is currently a Louis-Jeantet Professor of Genetics in the Department of Genetic Medicine and Development of the University of Geneva Medical School. He obtained his B.Sc. in 1995 and M.Sc. in 1997 in Biology from the University of Crete (Greece) and his PhD in 2001 from the PennsylvaniaStateUniversity in the US, studying the evolutionary biology and population genetics of regulatory DNA in mammals and Drosophila. His post-doctoral work was at the University of Geneva Medical School, focusing on comparative genome analysis and the functional characterization of conserved non-genic elements. He previously was an Investigator and Senior Investigator at the Wellcome Trust Sanger Institute since April 2004. His current research focuses on the genetic basis of regulatory variation and gene expression variation in the human genome (see also, the processes that govern non-coding DNA evolution. He has authored and co-authored more than 50 papers in peer-reviewed journals with more that 20 of them in journals such as Nature, Science and Nature Genetics. His papers have attracted more than 4000 citations and his H-factor is 27. He has been invited to give talks and keynote lectures in the most prestigious genetics meeting in the world and is the organizer of multiple training courses including the Wellcome Trust HapMap course and co-organizer of the Wellcome Trust School of Human Genomics with Leena Peltonen. He has served as an analysis co-chair in the pilot phase of the ENCODE (ENCyclopedia Of Dna Elements) consortium and member of the analysis group of the Mouse Genome Sequencing Consortium and the International HapMap project. He now has a leading analysis role in the extension of the HapMap (aka HapMap3 project) and is a member of the analysis group of the 1000 genomes project. He currently serves in the Board of Reviewing Editors of Science, and he is a Senior Editor in PLoS Genetics.

Key publications:
Dermitzakis E.T. and A.G. Clark. 2009. Genetics. Life after GWA studies. Science. 326: 239-240
Dimas A.S., S. Deutsch, B.E. Stranger, S. Montgomery, C. Borel, H. Attar-Cohen, C. Ingle, C. Beazley, M. Gutierrez Arcelus, M. Sekowska, M. Gagnebin, J. Nisbett, P. Deloukas, E.T. Dermitzakis*, S.E. Antonarakis*. 2009. Common regulatory variation impacts gene expression in a tissue-dependent manner. Science 325: 1246-1250
Dimas, A., B.E. Stranger, C. Beazley, C. Ingle, R. Finn, M. Ritchie, M. Dunning, P. Deloukas, S. Tavare and E.T. Dermitzakis. 2008. Exploring epistatic effects between regulatory and protein-coding variation. PLoS Genetics e1000244
Stranger, B.E., A. Nica, A. Dimas, M.S. Forrest, C. Beazley, M. Dunning, C.P. Bird, C.E. Ingle, D. Koller, S. Tavaré, P. Deloukas and E.T. Dermitzakis. 2007. Population genomics of human gene expression. Nature Genetics 39: 1217-1224.
Stranger, B.E., M.S. Forrest, M. Dunning, C.E. Ingle, C. Beazley, N. Thorne, R. Redon, C. Lee, C. Tyler-Smith, N. Carter, S.W. Scherer, S. Tavaré, P. Deloukas, M.E. Hurles and E.T. Dermitzakis. 2007. Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 315: 848-853.



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