Prof Gil Ast

Professor of Molecular Biology and Bioinformatics
Department of Human Molecular Genetics and Biochemistry
Tel Aviv University Medical School

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Our group has made seminal contributions to our understanding of the acquisition of complexity in the expression of genomic information through alternative mRNA splicing, and the involvement of this process in genetic disorders and cancer. The broad focus of our laboratory is on regulation of splicing of pre-mRNA and the importance of alternative splicing in the generating transcriptomic diversity unique to our species. We study mechanisms of alternative splicing regulation using a combination of computational and experimental methods. We also study the potential link between DNA packaging by histones and epigenetic modifications and how these effect processing of pre-mRNA.



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